# The 12 Biggest Upsets in MMA History

> Some of these results still get argued about a decade later, and a couple of them ended a career on the spot.

*By YPB Team · Published August 5, 2026 · https://youpick.best/ranking/the-12-biggest-upsets-in-mma-history*

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## Current results (0 votes)

1. **Holly Holm beats Ronda Rousey**
   Holm ended the sport's biggest unbeaten run with a second-round head kick at UFC 193 in November 2015.
2. **Matt Serra beats Georges St-Pierre**
   A reality-show winner and heavy underdog stopped the welterweight champion in the first round at UFC 69.
3. **Chris Weidman beats Anderson Silva**
   Silva clowned his way into a left hook at UFC 162, ending the longest title reign in UFC history.
4. **Fabricio Werdum beats Fedor Emelianenko**
   A triangle-armbar in under two minutes ended Fedor's decade-long unbeaten streak in 2010.
5. **Julianna Pena beats Amanda Nunes**
   Pena took a beating, then choked out the pound-for-pound queen in round two at UFC 269.
6. **Leon Edwards beats Kamaru Usman**
   Losing on the cards with a minute left, Edwards landed a head kick that took the welterweight belt.
7. **Michael Bisping beats Luke Rockhold**
   Called up on seventeen days' notice, Bisping knocked out the champion and finally won a belt at 37.
8. **Renan Barao loses to TJ Dillashaw**
   Dillashaw walked in as a 10-1 underdog and battered the pound-for-pound favourite for five rounds.
9. **Holly Holm loses to Miesha Tate**
   Tate survived five rounds of striking to choke Holm unconscious and take the belt at UFC 196.
10. **Kevin Randleman beats Mirko Cro Cop**
   Randleman flattened the feared striker in twenty seconds at Pride Total Elimination 2004.
11. **Antonio Rodrigo Nogueira beats Tim Sylvia**
   Beaten up for a round and a half, Nogueira found a guillotine to win the interim heavyweight title.
12. **Sean Strickland beats Israel Adesanya**
   A 5-1 underdog dropped the middleweight champion in round one and out-boxed him for the belt.

Tags: sports, ufc, all-time, mma